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and theophylline controls the glucose metabolism [27]
Glypican-4 enhances insulin signaling via interaction with the insulin receptor and serves as a novel adipokine

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Mice were housed in a specific pathogen-free facility, maintained in a controlled environment (222C, 50 10% humidity, 12 h light/dark cycle) and provided ad libitum access to food and water

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If confirmed, this would be a significant tolerability advantage
