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Blood 111 , 37933801, doi: 10.1182/blood-2007-07-104042 (2008)

Immunopositivity for HIF-1 was observed in cellular components of both uterine fibroids and the surrounding myometrium

One confounding factor is the complexity of antioxidants, referred to by Halliwell [6] as the antioxidant paradox, or the situation in which antioxidants such as glutathione can possess prooxidant activity causing a hormetic effect enabling the body to bolster its endogenous antioxidant defenses

Instead of applying something topically, these are injected to work internally

doi: 10.2174/1381612824666181112112857

Colloids Surf., B 2018, 169, 313320