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Weight loss can open the door to a healthier, more fulfilling life, but it is not the whole story

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Although no approved therapeutic strategies exist to treat or prevent progression of stage B DCM, ongoing efforts target various pathological mechanisms

However, they also introduce a new variable into the bodys regulatory system: a constant external signal that overrides the bodys natural hormone cycles

The imbalance of gut microbiota will reduce the production of SCFAs, weaken the ability to activate SCFAs receptors, and affect GLP-1 secretion, resulting in abnormal glucose metabolism and lipid metabolism (Ma et al., 2019)

And drugging this target has proven hard