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Hypertension: GLP-1RAs modulate the carotid body pathway, attenuating sympathetic excitability for BP control

Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study

BMC Complement Altern Med (2017) 17:395

Khaity, A

In the GLP-1 RA vs DPP-4 inhibitor cohort, we observed the same pattern

As weight loss with any existing pharmaceutical intervention inevitably plateaus due to putative counterregulatory mechanisms, we further hypothesized that the postulated enhanced body weight suppressive effects of combined amylin- and GLP-1R-based pharmacotherapies could be even further enhanced if the drugs were introduced in a stepwise fashion, allowing the physiological systems to adjust to and overcome the tachyphylaxis that occurs with repeated drug treatments 21,22,23