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Lipid-Lowering Therapies Traditional lipid-lowering therapies statins, ezetimibe, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, inclisiran, and bempedoic acid primarily reduce circulating apolipoprotein B (ApoB)containing lipoproteins, which both retards new atherogenesis and, at sufficient magnitude, drives angiographic plaque regression [15][17]