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Bone scintigraphy revealed multiple foci of dispersed hyperuptake, suggestive of multiple fragility fractures of cervical and dorsal vertebrae, costal arches and lesser trochanter, confirmed by CT

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Mutated GST sequences were subcloned into pET-15b, pET-24d, pGEX 4T-1, and pCMV-2B expression vectors, and the mutated constructs were confirmed by DNA sequencing