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First, in vitro studies predominantly use immortalized cell lines (e.g., HepG2, L02) or primary hepatocytes under simplified lipid overload conditions, failing to recapitulate the complex in vivo microenvironment of NAFLDincluding crosstalk between hepatocytes, hepatic stellate cells, and immune cells, or systemic metabolic dysregulation

Another study that was conducted around the same time confirmed the results of the above studies

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Fucoxanthin: 13 mg/day has been shown to reduce body weight, BMI, and abdominal fat [22]

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