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This, in summary, could cause fatigue directly, for example, owing to a diminished energy supply or hypotension

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Further, our analyses revealed that the multi-omics signature associated with higher circulating TMAO concentrations and, therefore, elevated cardiovascular risk, shifted from obesity with increased insulin resistance toward overt T2D and IHD with only three variables (age, eGFR, and serum butyryl-carnitine) consistently being strong contributors across models built with the BMIS, T2D and IHD disease groups

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[DOI] [PMC free article] [PubMed] [Google Scholar] 121.Ferro F, Ouill A, Tran T-A, Fontanaud P, Bois P, Babuty D et al

These different findings need to be validated by a large-scale analysis including a greater number of individuals with a balanced representation of both genders