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The most efficient absorption zone is the central depression on the floor of the mouth, directly under the tip to mid-body of the tongue

doi: 10.1136/bmj.r845

Drug Delivery Transl Res 12:16 Liang Y, Ruihuan D, Huihui W, Lanze L, Jibiao H, Yuping T, Zhenyu Z, Jie Z, Aiping W, Kaoxiang S, Youxin L, And Shi Y (2022) Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption

Furthermore, Talay et al [56] have shown that proactive, personalized lifestyle coaching design significantly enhances patient engagement in semaglutide-supported programs, while another study by Talay et al [57] highlights the robust efficacy of tirzepatide-supported digital interventions [58]

However, their impact as a true public health intervention remains limited by cost, adherence challenges, and infrastructure gaps in long-term care delivery
