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However, patients may experience various changes after discontinuation that are related to the loss of the medication's therapeutic effects rather than withdrawal per se

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In animal models, CagriSema preserved energy expenditure during weight loss by maintaining mitochondrial leak respiration in skeletal muscle

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Furthermore, GLP-1 RAs have beneficial effects for reducing the risk of MI or endpoints composed of coronary events (e.g., MACE, cardiovascular mortality), while solid evidence on CCS, vasospastic angina, and MVA is lacking