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These medications are not recommended during pregnancy or breastfeeding, and women of childbearing potential should use effective contraception

In this context, data obtained from experimental studies are often inconsistent when compared with those conducted on humans, and many aspects require deeper investigations (e.g., role of DPP-4 in different cell types, temporal and spatial characteristics of DPP-4 expression across different disease stages, identification of possible ligands for DPP-4, and approaches for targeting nonenzymatic DPP-4 activity) [46,80]

Diets high in potassium may help reduce a person's risk of osteoporosis by supporting bone mineral density

As the WL achieved with the novel obesity pharmacotherapies approaches that of bariatric surgery, we will need to assess whether long-term complications observed after bariatric surgery such as increased risk of osteoporosis, fractures, macro- and micronutrient deficiencies as well as self-harm behaviours will also be present with pharmacotherapy [112, 113]

Drinking enough water helps support normal urinary tract function and may help flush bacteria from the urinary system