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The dose chosen was based on an initial dose escalation study (ranging from 10 mg/kg/day to a total dose of 150 mg/kg/day) in DIO mice (n=2)
AOD 9604 meets the first two criteria clearly
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Taylor, StephenRapid Communications in Mass Spectrometry (2000), 14 (18), 1669-1673CODEN: RCMSEF
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Macro/microscopic failure was rapidly translated into a frozen behavior, with limited movements only, and an almost frozen rat, standing firmly on the surface with its posterior legs
