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Possible adverse effects of B12 treatment include injection-site reactions (with intramuscular preparations), and rarely hypersensitivity reactions including anaphylaxis

Chowdhury TA, Escudier V

But when demand surged beyond supply, both companies declared shortages with the FDA, opening the door for compounding pharmacies to enter the market

Research shows that while initial weight loss is achievable, maintaining it is difficult, with one analysis finding that more than half of lost weight is regained within two years, and over 80% within five years

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