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Tanaka Y, Abe Y, Oto Y, et al
Cardiovascular Risk Reduction Semaglutide SELECT demonstrated 20% MACE reduction with semaglutide in 17,604 patients

Insulin release is higher after enteral, but not intravenous, glucose administration

Numerous studies have shown that metformin not only reduces weight and metabolic disorders but also corrects menstrual patterns, restores ovulation, and even improves chances of pregnancy [154]

These findings suggest that retatrutide may offer broader cardiometabolic benefit beyond blood pressure reduction alone
