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When semaglutide strengthens this signal, patients typically experience a reduced appetite and slower stomach emptying

The Canadian market presents unique considerations

Development, preclinical, and early clinical data on the GIP/GLP-1 receptor agonist tirzepatide Among the GIP/GLP-1 receptor agonists, tirzepatide (LY3298176) is the compound that is the most advanced in development and the first substance in this class that has received approval for the therapy of T2D by the FDA in May 2022 (manufacturer Eli Lilly Comp., trade name Mounjaro ) (5355)

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These companies will need to understand how their demand may be impacted in the future, which part of their markets will be most affected, how their portfolio could evolve to mitigate the impact and how they can establish themselves as complementary to GLP-1RAs