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Moreover, we found that CD133 + cells, but not CD133 , accumulate more intracellular GSH in response to gemcitabine (Figure 6B)

These insights highlight the complexity of cGAS-STING signaling across different cancer types and underscore the need for patient stratification strategies, including genomic and epigenetic analyses, to optimize cGAS-STING targeted therapies

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The rate of weight loss mattersmore gradual reduction may cause fewer menstrual disruptions than rapid weight loss, though tirzepatide-induced weight loss occurs relatively quickly compared to lifestyle modification alone

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