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The more direct published evidence currently available concerns VEGFR2 expression, VEGFR2-Akt-eNOS signaling, and Src-Cav-1-eNOS pathway activation rather than the complete transcriptional-to-secretory VEGF sequence

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Dysregulation of this response results in systemic inflammation that contributes to AD

This suggested DSIP might modulate pain processing through mechanisms distinct from classical opioid pathways

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