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The Heaviness of Smoking Index is a 2-item measure that was derived from the Fagerstrm Tolerance Questionnaire

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This work may confirm why some studies of chronic nicotine/tobacco use show beneficial effects in animals and humans (computerized testing plus smoking satiety), while others do not (use of paper and pen tests and testing during withdrawal)

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Attention and inhibitory control are mediated by frontostriatal regions (side of the prefrontal cortex, the dorsal anterior the putamen, caudate, and cingulate cortex) [86]

Nicotine dependence may also make it more difficult for people to reduce or stop their cannabis use it they find its beginning to cause them problems