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Impact of Semaglutide on Cardiovascular and Renal Outcomes Substantial evidence from large multicentre, placebocontrolled RCTs has shown that treatment with onceweekly subcutaneous semaglutide (or other GLP1RAs) reduces the risk of adverse cardiovascular and renal outcomes, as well as hospitalisations for heart failure in patients with overweight or obesity, regardless of their T2D status [44]

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T2DM is the most significant and extensively studied comorbidity in MASLD, as reviewed recently