glp 1 agonist with dpp 4 inhibitor Clinical Use of DPP-4 Inhibitors Mechanism of action of DPP-4

Described as a disorder of glucose homeostasis and insulin sensitivity, it is primarily triggered by uncontrolled hyperglycemia, and it is responsible for a large number of microvascular (like diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy) and macrovascular complications (like diabetic foot syndrome, cerebrovascular events, and myocardial infarction) [5]

Furthermore, GLP-1 decreases glucagon secretion from pancreatic cells and has also extrapancreatic influences as a direct suppressive effect on appetite centers and a slowing of gastric emptying increasing the feeling of satiety

Both procedures can produce significant weight loss, but they work in different ways and may fit different patients

By activating GLP-1 receptors in multiple areas particularly the hypothalamus and vagus nerve this therapy helps reduce appetite, improve glycaemic control, and support healthier eating behaviours

& Schwarzbauer, J

The most likely cause of a withdrawal (If one were to occur) would probably be increased heart-rate caused by the agonisation of GLP1R and GR in particular [56] , [57] , effects that occur in part due to the expression of GLP1R and GR by the heart