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Balland E, Dam J, Langlet F, Caron E, Steculorum S, Messina A, et al

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In retrospect, perhaps too high

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The main enzyme involved, dipeptidyl peptidase-4 (DPP-4) also known as CD26, cleaves off the two N-terminal residues resulting in GLP-1 (9-36 amide) which is inactive or acts as an inhibitor at the GLP-1 receptor (23)

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Aetna typically requires BMI 30 with a comorbid condition (like hypertension or sleep apnea) or BMI 35 without comorbidities, plus documented diet and exercise failure

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Theres been a lot of hype around pancreatitis, gallbladder complications, concerns for thyroid cancer so, this has really not been shown in human studies, that this is a downstream complication

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