tirzepatide surpass trials SURPASS-CVOT Published: Large Trial Confirms CVD Efficacy of Once-weekly tirzepatide versus once-daily insulin

But MDLs aren't perfect

2024 Springer Review Neeland et al.) Every extra ~50 cm raises the risk of dying early by 40100% (2022 Frontiers Mortality Study Jayedi et al.) People with high visceral fat lose 515 healthy years of life (2025 NHANES Lifespan Study Xue/Zhang et al.) How to Measure Visceral Fat Accurately How Much Visceral Fat Is Too Much

Ongoing studies may soon impact regulatory approval and treatment guidelines

For patients seeking a non-injectable weight loss treatment, oral GLP-1 therapies are becoming an increasingly important option alongside weight loss injections, gastric balloons and bariatric surgery

[3:17] Jeff Langford Well, I love that 3P approach, Andrea protein, plate or portion, and plenty of water and fiber

Semaglutide may support better hormone balance by: Improving insulin resistance (a major hormone disruptor) Reducing excess body fat Lowering inflammation For women with estrogen dominance related to weight, this can be a meaningful shift