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At 1mg, patients may experience appetite reduction and gradual weight change, but the expected magnitude is typically lower than what was demonstrated in obesity-specific trials

The distinction between research use and personal use matters significantly from a regulatory perspective

How safety data affects the approval timeline The dysesthesia signal will not necessarily prevent approval, but it will shape the labeling and potentially the approved dose range

Few expect their skin to feel fundamentally different

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The most common are weight gain and gastrointestinal issues