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Investigating the functional connectivity between central glucagon-like peptide-1 (GLP-1) and glutamatergic signaling: a systematic review Published online by Cambridge University Press: 29 January 2026 Abstract Glutamatergic neurons represent 40% of neurons in the human central nervous system

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This effect prompted a cascade of further studies: The STEP trials demonstrated that semaglutide 2.4 mg led to ~15% average weight loss in people without diabetes

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