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Cho, J., Ahn, Y., Lee, D., & Son, C

Biochim Biophys Acta 1830(5):31733181 Begara-Morales JC et al (2018) Nitric oxide buffering and conditional nitric oxide release in stress response

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Thus, 1D228 could target both endothelial cells and tumor cells by inhibition of c-Met and TRK signaling, which produced a synergistic anti-tumor effect

There is an activation barrier of about 10 kcal/mol for this interconversion, since the high-energy half-chair conformer is an intermediate in this process