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In obesity, pro-inflammatory cytokines, mainly interleukins IL-6, IL-1b and tumor necrosis factor (TNF-), are released and activate several serine kinases, including c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) [22,34,35]

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Physicians may recommend alternative approaches based on individual medical assessment, contraindications, or situations where risks outweigh potential benefits