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[23] These findings lead to the conclusion that the large quantities of free radicals contained in smoke enhance oxidative stress and, in combination with reduced NO bioavailability, nicotine-induced vasoconstriction and impaired vasodilation, may lead to endothelial dysfunction

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A ProPublica analysis of more than 100 tobacco deals since the settlement found that they are creating new fiscal headaches for states, driving some into bailouts or threatening to increase the cost of borrowing in the future

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