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Kidney and liver function As semaglutide binds strongly to albumin and is cleared slowly, any liver or kidney disease may influence clearance time

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doi:10.1001/jamaoncol.2025.2681 Wolff Sagy Y, et al

If successfully produced, oral GLP-1 agonists could revolutionize the market by improving patient adherence

However, if your current effective dose is still managing your appetite well with minimal side effects, staying on it longer may be more beneficial while your body adjusts to its new weight and metabolic rate