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Metabolism journal, a phase 2, prospective, double-blinded, randomized, placebo-controlled trial investigated the progression or regression of carotid total plaque volume (TPV) in participants with metabolic syndrome.[15] 157 individuals took part in the six-month study, with 76 participants receiving 2,000mg/day of oral L-Carnitine and 81 participants receiving placebo (cellulose)