is tradjenta a glp-1 Diagnosed With Type 2? It's Time to Consider Starting DPP-4 inhibitors for type 2

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doi: 10.2337/dc14-1625 46 RosenstockJAronsonRGrunbergerGHanefeldMPiattiPSerusclatPet al

GLP-1RAs have emerged as effective pharmacological agents for weight management by modulating central appetite regulation and energy homeostasis

GLP-1 receptor agonists also have favourable effects on albuminuria and may slow eGFR decline , though the evidence for hard renal outcomes is less robust than for SGLT2 inhibitors

Contact your healthcare provider promptly if you experience: Severe or persistent heartburn unresponsive to over-the-counter antacids or lifestyle modifications Difficulty swallowing (dysphagia) or painful swallowing (odynophagia), which may indicate esophageal inflammation or stricture Persistent nausea and vomiting that prevents adequate oral intake or leads to dehydration Vomiting blood (hematemesis) or material resembling coffee grounds Black, tarry stools (melena) or visible blood in stool Severe abdominal pain, particularly if localized to the upper abdomen or radiating to the back (stop medication immediately if pancreatitis is suspected) Right upper quadrant pain, fever, or yellowing of skin/eyes, which may indicate gallbladder disease Unintentional weight loss beyond expected therapeutic effects New or worsening chest pain (call 911 if concerning for heart attack), especially if accompanied by shortness of breath These symptoms may indicate complications such as erosive esophagitis, gastrointestinal bleeding, pancreatitis, or gastroparesis