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Isolated colonic crypt cultures were used to assess the effects of propionate on gut hormone release in vitro

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They lost about 8% of their body weight in 24 weeks.1 Individuals who gained back some weight after surgery lost almost 9% of their body weight after six months of taking liraglutide or semaglutide.2 People who had surgery and started gaining weight again lost about 10-15% of their weight after six months of taking semaglutide or tirzepatide.3 In summary, obesity is a complex disease that requires a variety of tools to manage it long-term