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Low nephron endowment at birth, which heightens the lifetime risk of CKD, associates with low birth weight for gestational age, prematurity, adverse intrauterine exposure (e.g., preeclampsia, high levels of maternal blood glucose and blood pressure, and xenobiotics exposure 65,66 ), low socioeconomic status, poor nutrition, and childhood illness

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Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2

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Additionally, tirzepatide use was associated with a lower risk of mortality (HR, 0.52

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