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GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans

Unfortunately, the history of AOM has been fraught with the abrupt withdrawal of several medications due to adverse effects (eg, sibutramine, lorcaserin, rimonabant and fenfluramine-phentermine)

This gradual approachsometimes called 'dose titration pausing'gives your system more time to adapt

Nat Rev Dis Primers (2016) 2:16057

Retatrutide acts through a triple-agonist mechanism targeting the GLP-1, GIP and glucagon receptors

At the hypothalamus level, food intake reduction occurs either through direct action at GcgR within the arcuate nucleus or via GcgR-expressing afferent vagal nerves from the liver [14]