glp 1 define Glucagon-like peptide (GLP-1) Glucagon Like Peptide 1 Receptor

Front Endocrinol (Lausanne) [Internet]

Obesity and overweight, which are common in patients with DM2, are a factors that favor the development/progression of CKD through both direct and indirect effects.69 Although the precise mechanisms the association between obesity and CKD are not totally defined it has been proposed that hypertension, glomerular hyperfiltration, hyperglycemia, lipid toxicity, inflammation or the role of adipose tissue and its adipokines are involved.70 Weight reduction by bariatric surgery, pharmacological treatment or dietary measures are associated with a nephroprotective effect,7173 so that weight reduction is a fundamental objective in the nephroprotection of patients with DKD

If tirzepatide stopped working Distinguish between true pharmacological tolerance and a weight loss plateau caused by metabolic adaptation

Pros: Long track record of safety

wrote the initial draft with H.M.P., E.F., S.L.B., S.D.G., B.M., and D.C.P

Wyne KL, Litwin SE, Cusi K, Guyton JR