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Clinically, the FDA approval of semaglutide (Wegovy ) marks a significant advance in obesity therapy, demonstrating not only substantial weight reduction but also reduced cardiovascular risk in high-risk populations [242]

Increased autophagy in the target tissues of insulin improves insulin sensitivity by decreasing ERS 4

The field is primed for optimizing precision approaches for the benefit of patients suffering with chronic metabolic disease

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Patients taking semaglutide 2.4mg lost an average of 14.9% of their body weight over 68 weeks, with 86.4% achieving at least 5% weight loss and nearly half losing 15% or more

doi: 10.1016/S2213-8587(21)00115-7