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4 GLP-1/GIP Receptor Co-Activation and Downstream Effects Activation of the GLP-1 receptor has been shown to decrease glucose, reduce appetite, lower body weight, and improve insulin sensitivity in patients with type 2 diabetes, obesity, or both

[37] observed that after internalization, GLP-1R/ligand complex could be co-localized with adenylate cyclase in the endosome

Contraceptive Interactions Because GLP-1 RAs slow gastric emptying, they may decrease absorption of oral contraceptives, particularly during dose escalation phases