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Description
Cardiovascular Safety Heart rate increases of approximately 2-6 beats per minute have been observed with orforglipron across clinical trials, consistent with the class effect of GLP-1 receptor agonists
Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work
Orforglipron ended up with Lilly, which licensed it from Chugai in 2018
This dual phenotype has detrimental effects on both clinical and patient-centred outcomes, including functional limitations and increased morbidity risk (e.g., type 2 diabetes, fractures), contributing to lower quality of life and survival rates [8]
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer
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