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Cloning of rat and human pancreatic GLP-1R cDNA documented that ligand-induced activation of a single unique GLP-1R increases intracellular levels of cAMP and also that GLP-1, but not glucagon, GIP, VIP, or secretin, activates GLP-1R [[360], [361], [362], [363], [364]]

Insulin helps the body use sugar for energy

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Implications and Future Directions The GLP-1 manufacturing ramp-up has profound implications across healthcare and industry: Patient access vs equity: In the short term, supply constraints may limit patient access despite massive investments