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Circulation 2022;145:565-74.

Important topics include: Potential drug interactions between GLP-1 medications and DMARDs Monitoring strategies for both conditions Whether weight loss might improve RA symptoms or treatment response Cardiovascular risk reduction strategies Safety considerations including contraindications (personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) Patients should not discontinue or modify DMARD therapy based on unproven theories about GLP-1 medications treating RA

Contrave and Qsymia are both effective at managing obesity

Patients often see sustained improvements in blood sugar stability even as they lose weight and reduce calorie intake

ACHD providers should ask open-ended questions to determine the patients understanding of their congenital heart disease and then provide education as needed

users are advised to administer Mounjaro at the same time each week to maintain stable medication levels