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23.Wickham H, Girlich M

Beyond that: Consider Tirzepatide If: You want an FDA-approved, commercially available medication You have type 2 diabetes (Mounjaro is specifically approved for this) You prefer a medication with more long-term safety data Your insurance covers tirzepatide You need predictable access to medication supply Consider Waiting for Retatrutide If: You've plateaued on other GLP-1 medications You're interested in the potential metabolic benefits of glucagon activation You're comfortable waiting for FDA approval (expected 2027) You want potentially greater fat loss based on early trial data Switching From Tirzepatide to Retatrutide No established dose conversion exists

The Association of Anaesthetists , in collaboration with the Royal College of Anaesthetists (RCoA), Centre for Perioperative Care (CPOC), and the Joint British Diabetes Societies (JBDS), has published recommendations addressing the management of patients taking these medications before surgery

The GLP-1 fatigue management guide covers strategies in depth

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