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Those hardened lumps are not just unsightly

As this is a narrative rather than a systematic review, the potential for selection bias exists, and restriction to English-language studies may have introduced language bias

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At the start of the study, each participant indicated her or his diet soda intake as none (less than 1 per month), light (1 diet soda a month to 6 diet sodas a week), or daily (1 or more a day)

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simultaneously, IBD-related genetic markers (NOD2, IL23R) influence baseline gut barrier function and inflammatory state