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Published in Nature Medicine, the BARI-STEP trial, led by Dr Janine Makaronidis at the UCL Centre for Obesity Research, looked at use of semaglutide at a dose of 2.4mg in patients who had not responded well to bariatric surgery
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9294 Despite the variability in clinical studies, preclinical research has focused on understanding the role of DPP4 in inflammation and the development of T1DM

Myosteatosis alters muscle fiber composition and organization, with a decrease in oxidative, insulin-sensitive fibers and a concomitant increase in relatively fast-fatiguing glycolytic fibers, paralleling the effects observed in obesity and aging

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