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doi: 10.1080/02699052.2019.1587000 21 LaurindoLFBarbalhoSMGuiguerELda Silva Soares de SouzaMde SouzaGAFidalgoTMet al

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cohort study, the 2-year discontinuation rate for GLP-1 receptor agonists was 64.1% among people with type 2 diabetes mellitus, driven by factors such as older age, low income, gastrointestinal adverse events, and insufficient weight loss [115]

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82 For patients with obesity and HFpEF, GLP-1 RAs, such as semaglutide, are safe, with fewer serious cardiovascular events reported

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These effects were more common in the semaglutide group than in the placebo group

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