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Saxenda also has a risk of thyroid tumours

GLP-1RAs may modulate inflammation by reducing circulating pro-inflammatory cytokines such as TNF- and IL-6, which promote proteolysis via the ubiquitin-proteasome pathway [9]

Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimers disease

Moreover, in DNA methylation alterations of tumor cells induced by GLP-1RAs, studies have demonstrated that during breast cancer progression, tumor suppressor genes such as ESR1, CDH1, and ADAM33 are downregulated due to hypermethylation alterations in their promoter regions

Theres low-level constant inflammation, immune dysfunction, high levels of hormones like insulin and leptin

Associations of socioeconomic status and healthy lifestyle with incident early-onset and late-onset dementia: A prospective cohort study