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[1] [2] The most commonly reported side effects in clinical trials were gastrointestinal, including nausea (occurring in 12-29% of patients), diarrhea, vomiting, constipation, and abdominal discomfort

Rotate injection sites with each dose to prevent tissue changes that can affect absorption

Greater Weight Loss Clinical Trial Data: In the Phase 2 TRIUMPH-1 study , retatrutide achieved unprecedented levels of weight loss : Up to 24.2% average total body weight loss at 48 weeks Over 26% weight loss at the highest dose (12 mg weekly) In comparison: Tirzepatides weight loss peaked at about 22.5% in SURMOUNT-1 at 72 weeks This suggests faster, more significant fat loss in less time with retatrutide

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The semaglutide expiration guide covers these timelines in detail

Severe hypoglycemia requires emergency glucagon administration and medical attention