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Further studies to characterize the good and poor responders are encouraged in the future

GLP-1 improves the neuronal supportive ability of astrocytes in alzheimers disease by regulating mitochondrial dysfunction via the cAMP/PKA pathway

Unlike traditional GLP-1 agonists that target a single receptor pathway, tirzepatide simultaneously activates both GLP-1 and glucose-dependent insulinotropic peptide (GIP) receptors

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Here, we present a ligand-based proximity labeling approach to interrogate the native cell membrane interactome for the GLP-1 receptor after agonist simulation