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In early studies, selective knockout of the GPX4 gene in hippocampal neurons promotes neurodegeneration and cell death in a non-apoptotic manner, which provide preliminary evidence for GPX4 as a particular regulator of ferroptosis (Seiler et al., 2008)
Solomon 2016
doi: 10.1002/JLB.3MA1220-815RRR
Neuroinflammation 14 (1), 179179
SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor
