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At an earlier stage, apolipoprotein B starts retaining in the sub-endothelial spaces which activates endothelial cells to secrete chemokines which then recruit monocytes

Early clinical experiments showed that a continuous intravenous infusion of native GLP-1 could nearly normalize blood glucose levels in people with type 2 diabetes ( [41] ) ( [39] )

Aunque la evidencia preclnica sugiere efectos cardioprotectores, los beneficios cardiovasculares demostrados clnicamente provienen de estudios con agonistas del receptor de GLP-1 especficos (como liraglutida, semaglutida y dulaglutida), que han mostrado reduccin de eventos cardiovasculares mayores en pacientes con diabetes tipo 2

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Changes in A1C at 26 weeks were 1.51%, 1.30%, 0.99% and 0.46% for the dulaglutide 1.5 mg, dulaglutide 0.75 mg, exenatide and placebo groups, respectively (both doses of dulaglutide were superior to exenatide
