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Organs such as the kidney, lungs, liver, heart, and even the brain are not left out from this insult, potentially resulting in what is called multiple organ damage (MOD) (Munji et al., 2019

14 In addition, the SMI is not dependent on a patients ability to generate sufficient PIF for effective drug delivery

Ludford K, Ho WJ, Thomas JV, Raghav KPS, Murphy MB, Fleming ND, Lee MS, Smaglo BG, You YN, Tillman MM, Kamiya-Matsuoka C, Thirumurthi S, Messick C, Johnson B, Vilar E, Dasari A, Shin S, Hernandez A, Yuan X, Yang H, Foo WC, Qiao W, Maru D, Kopetz S , Overman MJ

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Sobeh et al., 2018)

This range minimizes the risk of causing discomfort, such as burning or stinging sensations, and protects the mucosal lining from irritation
