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In response to inflammation and OxS, the activated HO-1 is a powerful down-regulator of pro-coagulant factors to prevent thrombotic events, endothelial injury from vascular inflammation, resolve FeRD and reset HMRD in COVID-19 and PASC patients 27,46

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We prepared 100 mL of reaction mixture (-keto glutarate 15 mM, ascorbate 5 mM, TML 5 mM, FeSO 4 200 M, TEA 20 mM, DTT 1 mM, TMLD 10 M) in a flask agitated for 30 min at 37 C

TMABA produces 4-N-trimethylaminobutyrate (-butyrobetaine) under the action of dehydrogenase (11)